Brock Purdy, Christian McCaffrey and the 49ers eliminated the defending Super Bowl champion Eagles, the Patriots dominated the Chargers and Josh Allen willed the Bills past the Jaguars.
When Indiana met Oregon in October, the game served as the best test yet of whether the Hoosiers were a one-year wonder or a program that was here to stay.
Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers' final pass 74 yards for a score in a 48-27 victory over the Indianapolis Colts on Monday night.
Jaylen Warren rushed for 143 yards and two touchdowns, Kenneth Gainwell caught a highlight-reel touchdown pass, and the Pittsburgh Steelers escaped with a 29-24 win over the host Detroit Lions on Sunday.