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Week 5 has its share of great games, including Alabama at Mississippi State, Washington at USC, and Florida at Missouri as part of the ten best picks against the spread.

Nebraska is unbeaten, but has anyone noticed? They look to keep rolling against a Maryland team in need of something positive. Here's the CFN preview and prediction.

It's been a rough start for both Purdue and Illinois, but the winner will finally be able to exhale. Here's the CFN preview and prediction.

Florida State needs a big win fast, but Virginia has a shot to make its own statement in the ACC race. Here's the CFN preview and prediction.

Indiana keeps on winning, but it hasn't been a dominant national title force yet. Rutgers will try to make this a game. Here's the CFN preview and prediction.

Washington and USC are each coming off their first losses of the season, but everything turns back around with a win.

Texas A&M lost its first two SEC games, and now Arkansas will try to make a bad situation for the Aggies even worse. Here's the CFN preview and prediction.

BYU gets back on the field after a week off, facing a desperate TCU that needs a big win fast. Here's the CFN preview and prediction.

Florida is rolling after a fantastic first month of the season, but Missouri is dangerous at home. Here's the CFN preview and prediction.

It's been a little while since Auburn and Tennessee played each other, and this time it's to stay in the SEC chase. Here's the CFN preview and prediction.