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A hormone called FGF21 can reverse obesity in mice by activating a newly identified brain circuit tied to metabolism. Surprisingly, it works in the hindbrain--the same region targeted by GLP-1 drugs like Ozempic and Wegovy--but through a completely . ...

Researchers have found a way to make cancer-killing immune cells more powerful and precise. By adding specific signaling components, they boosted the cells' readiness to attack tumors. Surprisingly, briefly suppressing the cells with a drug before .. ...

Scientists have discovered that a protein linked to cell death is secretly driving the aging of blood stem cells in a completely different way. Instead of killing the cells, it damages their mitochondria, sapping their energy and weakening the immune ...

A rogue set of "zombie" immune cells may be driving aging and fatty liver disease by flooding tissues with inflammation. Researchers found these cells accumulate with age and high cholesterol--and can make up most of the liver's immune cells in older ...

A massive, nearly 20-year study tracking over 650,000 Americans with irritable bowel syndrome is raising new questions about the long-term safety of common treatments. Researchers found that some widely used medications--including antidepressants and ...

New research suggests that aiming for a lower blood pressure target may deliver bigger heart health benefits than previously thought. Using large datasets and simulation models, scientists found that keeping systolic blood pressure below 120 mm Hg .. ...

A surprising new clinical trial has revealed that metformin--a cheap, century-old drug widely used for type 2 diabetes--may help people with type 1 diabetes in an unexpected way. While researchers initially hoped it would reduce insulin resistance, . ...

Feeling mentally "on" isn't just in your head--it can significantly boost what you accomplish. Researchers found that sharper thinking on a given day leads people to set bigger goals and actually follow through. That edge can equal up to 40 extra ...

A surprising discovery from high-altitude animals like yaks and Tibetan antelopes could reshape how we treat nerve damage in humans. Scientists found that a genetic mutation helping these animals survive low-oxygen environments also protects and ...

A massive Swedish study shows that AI can spot people at higher risk of melanoma using routine health data. Advanced models significantly outperformed basic methods, identifying high-risk groups with striking accuracy. Some individuals flagged by the ...