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Metformin, the world's most widely used diabetes drug, has long been recognized for its surprising range of benefits beyond lowering blood sugar, from reducing inflammation to lowering cancer risk. Yet its exact mechanism has remained unclear for ...

Overactivation of dopamine neurons may directly drive their death, explaining why movement-controlling brain cells degenerate in Parkinson's. Mice with chronically stimulated neurons showed the same selective damage seen in patients, along with ...

Scientists have decoded the 3D structure of an ancient viral protein hidden in our DNA. The HERV-K Env protein, found on cancer and autoimmune cells, has a unique shape that could unlock new diagnostics and therapies.

Virginia Tech researchers are investigating how overloaded mitochondria in the brain's memory circuits may spark early Alzheimer's damage. Their work focuses on calcium signaling and how it might trigger breakdowns in the entorhinal cortex.

Scientists at the University of Pennsylvania have shown for the first time that it's possible to detect dormant cancer cells in breast cancer survivors and eliminate them with repurposed drugs, potentially preventing recurrence. In a clinical trial, ...

A long-term study following insomnia patients treated with cannabis-based medical products revealed sustained improvements in sleep quality, mood, and pain management over 18 months. Most participants reported better rest and less anxiety or ...

High-ventilation breathwork with music can evoke psychedelic-like states, shifting blood flow in the brain and reducing negative emotions. Participants experienced unity and bliss, pointing to a natural therapeutic tool with powerful potential.

Once a universal feature of human psychology, the "unhappiness hump" in midlife has disappeared, replaced by a new trend: mental health is worst in youth and improves with age. Data from the U.S., U.K., and dozens of countries suggest today's young . ...

Japanese scientists have developed ADRIANA, a non-opioid painkiller that could provide powerful relief without the dangers of addiction. With successful trials already completed, large U.S. studies are now underway, raising hopes for a safer future . ...

A sweeping review of nearly 100 studies has raised concerns about the mental health impacts of high-potency cannabis products. Researchers found strong links to psychosis, schizophrenia, and cannabis use disorder, while results for anxiety and ...