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Researchers uncovered how fatty molecules called ceramides trigger acute kidney injury by damaging the mitochondria that power kidney cells. By altering ceramide metabolism or using a new drug candidate, the team was able to protect mitochondrial ...

Researchers have created a prediction method that comes startlingly close to real-world results. It works by aiming for strong alignment with actual values rather than simply reducing mistakes. Tests on medical and health data showed it often ...

Exercise appears to spark a whole-body anti-aging cascade, and scientists have now mapped out how it happens--and how a simple oral compound can mimic it. By following volunteers through rest, intense workouts, and endurance training, researchers ...

Ultra-endurance athletes can push their bodies to extraordinary extremes, but even they run into a hard biological wall. Researchers tracked ultra-runners, cyclists, and triathletes over weeks and months, discovering that no matter how intense the .. ...

Researchers have uncovered surprising evidence that anxiety may be controlled not by neurons but by two dueling groups of immune cells inside the brain. These microglia act like biological pedals--one pushing anxiety forward and the other holding it ...

Scientists studying aging found that sensory inputs like touch and smell can cancel out the lifespan-boosting effects of dietary restriction by suppressing the key longevity gene fmo-2. When overactivated, the gene makes worms oddly indifferent to .. ...

Smoking, vaping, or using both products significantly increases the likelihood of developing prediabetes and diabetes, and the risk is even higher among Hispanic, Black, and low-income groups. Researchers found that vaping alone raises prediabetes .. ...

Researchers have designed a smart drug that hunts down and breaks a little-known RNA that cancer cells depend on. The drug recognizes a unique fold in the RNA and triggers the cell to destroy it. Tests showed that removing this RNA slows cancer ...

Scientists have discovered strange microscopic structures in the blood of people with Long COVID--clusters of tiny microclots tangled together with sticky immune webs known as neutrophil extracellular traps, or NETs. These combined structures show up ...

Colchicine, a cheap and widely used gout drug, may help prevent heart attacks and strokes in people with cardiovascular disease. Trials involving nearly 23,000 patients show meaningful reductions in risk with low doses. Side effects were mostly mild ...