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Three studies in non-human primates show that strategically designed vaccines could prime a population of B cells to produce effective antibodies against HIV.

CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.

Nature - Author Correction: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma ...

The unique reactivity of transition metals has advanced C-H functionalization chemistry, enabling practitioners to directly modify drug and agrochemical compounds during Structure Activity Relationship (SAR) studies. These metals are particularly ...

Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plasticity, improves memory and network function and suppresses seizures.

Different tropical tree species can vary in their ability to withstand drought -- and so too, it seems, can distinct populations of the same tree species.

Ecologists have long wondered why some tropical forests store more carbon than others. A global satellite survey offers an explanation.

Cryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.

Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-respond control of diabetes in mouse and primate ...

An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.