Comprehensive pan-cancer analysis of loss of the Y chromosome (LOY) in benign and malignant cells establishes a new model linking LOY in circulating and tumour-infiltrating immune cells to LOY in malignant cells.
The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.
Atmospheric reanalyses combined with ocean observations and model simulations show that the extreme 2023 North Atlantic heatwave was primarily driven by anomalously weak winds leading to strongly shoaling mixed layers, with a smaller contribution ...