Structures of GDP-bound MOR-Gi conformational states combined with pharmacological assays show an inverse correlation between ligand efficacy and GDP affinity, where agonists decrease GDP affinity, promoting GTP exchange, and antagonists increase GDP ...
Researchers are preparing to trial the personalized base-editing therapy that saved a baby boy last year in at least five more children. Plus, get to know the real Francis Crick and what tree rings reveal about ancient coffins.
Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine exhibit improved antidepressant efficacy with reduced side ...
Somatically acquired mutations in the E1 ubiquitin-activating enzyme UBA1 within hematopoietic stem and progenitor cells (HSPCs) were recently identified as the cause of the adult-onset autoinflammatory syndrome VEXAS (vacuoles, E1 enzyme, X linked, ...
It is challenging to generate ultrashort laser pulses at high powers, but repeatedly overlapping light pulses in a crystal can efficiently amplify a weak signal.