The ZFTA-RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.
ATF6 activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.
The substantia nigra and all Parkinson's disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
A multiancestry phenome-wide analysis of copy number variants in the UK Biobank genomes increases power to detect genetic associations with complex traits across human populations.
The first melts generated in any solid-state mantle upwelling are kimberlitic CO2-rich silicate melts that form at about 250km depth through oxidation of elemental carbon to CO2.