Two-time defending champ Felix Auger-Aliassime fell to big-serving Giovanni Mpetshi Perricard 6-1, 7-6 (6), while Ben Shelton moved on to the quarterfinals.
Five-time major champion and former world No. 1 Maria Sharapova and Bob and Mike Bryan, the most successful men's doubles pairing in history, have been named as the International Tennis Hall of Fame's Class of 2025.
Alexander Zverev reached the quarterfinals at the Erste Bank Open by beating Marcos Giron 6-2, 7-5 on Wednesday for the German's personal-best 61st win of the year.
Stefanos Tsitsipas and Holger Rune kept alive their slim hopes of reaching the ATP Finals with wins at the Swiss Indoors tournament on Tuesday. Also advancing was sixth-seeded Ben Shelton.
Iga Swiatek, who has not competed since the U.S. Open in September, will return to action in the Billie Jean King Cup Finals in Malaga in November, Spain, she announced on social media.
Taylor Fritz and Denis Shapovalov expressed displeasure about the ITF's decision Monday to allow off-court coaching, saying it would change "the beauty of the game."