Hunter Renfrow and Tetairoa McMillan are in different parts of their careers, but they experienced a "homecoming" of sorts on Sunday, getting back to familiar ground, including the end zone.
When safety Demani Richardson recovered the kick, it gave the Panthers a chance for a game-winning drive, after they trailed 27-3 earlier in the second half.
With some help from Patrick Jones II on the rush, outside linebacker D.J. Wonnum pulled in an interception that sparked a rally for the Panthers against the Cardinals.
The Panthers came back with three second-half touchdowns and played much better defense, but the early hole they fell into doomed them in a loss at Arizona.
Facing the formidable James Conner and Kyler Murray, the Panthers defense put together their best rushing defensive performance since Week 3 of last season.
The Panthers finished the game without right guard Robert Hunt and center Austin Corbett, and both left the locker room with concerns after the loss to the Cardinals.
The Panthers fell to 0-2, after falling into an immediate 10-0 hole in the first quarter because of a pair of turnovers, which kept a dramatic late rallying from paying off.