Will Howard tossed three touchdown passes, but No. 4 Ohio State needed an interception by cornerback Jordan Hancock to seal its 21-17 win over Nebraska.
Quarterback Tayven Jackson threw for one touchdown and ran for another in his first start of the season as No. 13 Indiana pulled away from Washington, 31-17.
LSU heads to Kyle Field to take on Texas A&M in one of the weekend's biggest games. Plus, the Fighting Irish are set to square off against undefeated Navy, and Penn State travels to Camp Randall to face a suddenly hot Wisconsin team.