This isn't the first time Polis, who is seen as a possible 2028 Democratic presidential contender, has shown a willingness to butt heads with his party.
Collins ascended to the top Republican position on the House Judiciary Committee, subsequently emerging as a powerful defender of Trump during his impeachment.
His nomination to head the HHS by President-elect Donald Trump on Thursday could bring sweeping changes to the way Washington, D.C., targets health issues.
One day after the election, emergency contraception pill purchases increased by 930% in Texas, 730% in Indiana, and 133% in Oklahoma, according to Wisp data.